David Dastmalchian is originally from Kansas. He moved to Chicago, IL, to study acting at The Theatre School, DePaul University. After college, David worked as a professional fisherman in Alaska, a circus performer, movie theatre usher and playwright. He is an ensemble member of Shattered Globe Theatre Company and Caffeine Theatre in Chicago.　　David Dastmalchian was preparing to play college football on the east coast when he received an unexpected scholarship to study acting in Chicago.

2008年，参演的克里斯托弗·诺兰执导电影《蝙蝠侠：黑暗骑士》上映。

2012年，参演《寿司女郎》。

2015年，出演佩顿·里德执导漫威电影《蚁人》上映。

2017年，在电视剧《闪电侠》的第三季中饰演反派艾伯·阿卡迪巴。4月，证实将回归出演电影《蚁人与黄蜂女》。

2019年，加盟电影《沙丘》。